6-Methoxynicotinic acid → N-(7-Chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-6-methoxy-nicotinamide

HRID 1887860Notes

Reaction equation

HRID 1887860 reaction equation
[NH2:1][CH2:2][C:3]1[C:12](=[O:13])[C:11]2[C:6](=[CH:7][C:8]([Cl:14])=[CH:9][CH:10]=2)[N:5]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:4]=1.[CH3:21][O:22][C:23]1[CH:31]=[CH:30][C:26]([C:27](O)=[O:28])=[CH:25][N:24]=1>>[Cl:14][C:8]1[CH:7]=[C:6]2[C:11]([C:12](=[O:13])[C:3]([CH2:2][NH:1][C:27](=[O:28])[C:26]3[CH:30]=[CH:31][C:23]([O:22][CH3:21])=[N:24][CH:25]=3)=[CH:4][N:5]2[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 5924996-Methoxynicotinic acidHCID 712083983-(aminomethyl)-7-chloro-1-phenylquinolin-4(1H)-one

Product 1

HCID 71208877N-(7-Chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-6-methoxy-nicotinamide

Procedure

N-(7-Chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-6-methoxy-nicotinamide was prepared starting from intermediate D and 6-methoxy-nicotinic acid. MS calcd. for C23H18ClN3O3 [(M+H)+] 419.1, obsd. 420 [(M+H)+].

Sources & evidence

ORD record
ord-c860ab8b20644e17997db8aa8937ee75
Source dataset
uspto-grants-2013_08
Patent number
US08501732B2

Reaction notes

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