2-Dimethylamino-isonicotinic acid → N-(7-Chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-2-dimethylamino-iso-nicotinamide

HRID 1887866Notes

Reaction equation

HRID 1887866 reaction equation
[NH2:1][CH2:2][C:3]1[C:12](=[O:13])[C:11]2[C:6](=[CH:7][C:8]([Cl:14])=[CH:9][CH:10]=2)[N:5]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:4]=1.[CH3:21][N:22]([CH3:32])[C:23]1[CH:24]=[C:25]([CH:29]=[CH:30][N:31]=1)[C:26](O)=[O:27]>>[Cl:14][C:8]1[CH:7]=[C:6]2[C:11]([C:12](=[O:13])[C:3]([CH2:2][NH:1][C:26](=[O:27])[C:25]3[CH:29]=[CH:30][N:31]=[C:23]([N:22]([CH3:21])[CH3:32])[CH:24]=3)=[CH:4][N:5]2[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 64842342-Dimethylamino-isonicotinic acidHCID 712083983-(aminomethyl)-7-chloro-1-phenylquinolin-4(1H)-one

Product 1

HCID 71208316N-(7-Chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-2-dimethylamino-iso-nicotinamide

Procedure

N-(7-Chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-2-dimethylamino-iso-nicotinamide was prepared starting from intermediate D and 2-dimethylamino-isonicotinic acid. MS calcd. for C24H22ClN4O2 [(M+H)+] 433.1, obsd. 432.9.

Sources & evidence

ORD record
ord-69035be51b924d2680e742dabc30400b
Source dataset
uspto-grants-2013_08
Patent number
US08501732B2

Reaction notes

Loading…