4-(1,3-Oxazol-5-yl)benzoic Acid → N-(7-Chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-4-oxazol-5-yl-benzamide

HRID 1887872Notes

Reaction equation

HRID 1887872 reaction equation
[NH2:1][CH2:2][C:3]1[C:12](=[O:13])[C:11]2[C:6](=[CH:7][C:8]([Cl:14])=[CH:9][CH:10]=2)[N:5]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:4]=1.[O:21]1[C:25]([C:26]2[CH:34]=[CH:33][C:29]([C:30](O)=[O:31])=[CH:28][CH:27]=2)=[CH:24][N:23]=[CH:22]1>>[Cl:14][C:8]1[CH:7]=[C:6]2[C:11]([C:12](=[O:13])[C:3]([CH2:2][NH:1][C:30](=[O:31])[C:29]3[CH:28]=[CH:27][C:26]([C:25]4[O:21][CH:22]=[N:23][CH:24]=4)=[CH:34][CH:33]=3)=[CH:4][N:5]2[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 27764144-(1,3-Oxazol-5-yl)benzoic AcidHCID 712083983-(aminomethyl)-7-chloro-1-phenylquinolin-4(1H)-one

Product 1

HCID 71208268N-(7-Chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-4-oxazol-5-yl-benzamide

Procedure

N-(7-Chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-4-oxazol-5-yl-benzamide was prepared starting from intermediate D and 4-oxazol-5-yl-benzoic acid. MS calcd. for C26H18ClN3O3 [(M+H)+] 455.9, obsd. 456.0.

Sources & evidence

ORD record
ord-0a306238b4a341febc6b9d8187a4ef13
Source dataset
uspto-grants-2013_08
Patent number
US08501732B2

Reaction notes

Loading…