4-Piperidineethanol → HCID 71217355, compound

HRID 1887886Notes

Reaction equation

HRID 1887886 reaction equation
Cl[C:2]1[CH:29]=[CH:28][C:5]([C:6]([NH:8][CH2:9][C:10]2[C:19](=[O:20])[C:18]3[C:13](=[CH:14][C:15]([Cl:21])=[CH:16][CH:17]=3)[N:12]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH:11]=2)=[O:7])=[CH:4][N:3]=1.[OH:30][CH2:31][CH2:32][CH:33]1[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]1>>[Cl:21][C:15]1[CH:14]=[C:13]2[C:18]([C:19](=[O:20])[C:10]([CH2:9][NH:8][C:6]([C:5]3[CH:28]=[CH:29][C:2]([N:36]4[CH2:37][CH2:38][CH:33]([CH2:32][CH2:31][OH:30])[CH2:34][CH2:35]4)=[N:3][CH:4]=3)=[O:7])=[CH:11][N:12]2[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 739534-PiperidineethanolHCID 714870636-chloro-N-((7-chloro-4-oxo-1-phenyl-1,4-dihydroquinolin-3-yl)methyl)nicotinamide

Product 1

HCID 71217355HCID 71217355, compound

Procedure

4-(2-Hydroxy-ethyl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-5′-carboxylic acid (7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-amide was prepared starting from intermediate E and 4-(hydroxyethyl)piperidine. 1H NMR (400 MHz, DMSO-d6) δ ppm 8.50 (d, J=2.01 Hz, 1H) 8.43 (t, J=5.65 Hz, 1H) 8.21 (d, J=9.04 Hz, 1H) 7.80-7.88 (m, 2H) 7.54-7.65 (m, 3H) 7.49-7.53 (m, 2H) 7.38 (dd, J=8.66, 1.88 Hz, 1H) 6.84 (d, J=2.00 Hz, 1H) 6.72 (d, J=8.78 Hz, 1H) 4.25-4.33 (m, 5H) 3.38 (q, J=6.10 Hz, 2H) 2.75 (t, J=12.50 Hz, 2H) 1.58-1.67 (m, 3H) 1.28 (q, J=6.53 Hz, 2H) 0.92-1.05 (m, 2H).

Sources & evidence

ORD record
ord-5b0e59b11b824b70bc4b6db1b1be9a6b
Source dataset
uspto-grants-2013_08
Patent number
US08501732B2

Reaction notes

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