反应详情

2-(4-Hydroxypiperidin-1-yl)-thiazole-5-carboxylic acid (7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-amide was prepared starting from intermediate F and 4-hydroxypiperidine. 1H NMR (400 MHz, DMSO-d6) δ ppm 8.48 (t, J=5.54 Hz, 1H) 8.25 (d, J=8.66 Hz, 1H) 7.91 (s, 1H) 7.78 (s, 1H) 7.59-7.71 (m, 3H) 7.54-7.59 (m, 1H) 7.43 (dd, J=8.66, 2.01 Hz, 1H) 6.88 (d, J=1.81 Hz, 1H) 4.79 (d, J=4.03 Hz, 1H) 4.26 (d, J=5.44 Hz, 2H) 3.69 (dd, J=12.59, 4.53 Hz, 3H) 3.20 (ddd, J=13.09, 9.37, 3.53 Hz, 2H) 1.70-1.81 (m, 2H) 1.39 (td, J=8.66, 4.23 Hz, 2H).