HuagongsheHuagongshe Chemistry Print Report · For research reference only
Donepezil → Donepezil methanesulfonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Donepezil | HCID 3152 | — |
| Reactant | Methanesulfonic Acid | HCID 6395 | — |
| Solvent | Acetone | HCID 180 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Donepezil methanesulfonate | HCID 131730793 | — |
Reaction Steps
3.79 g of Donepezil is dissolved in 80 ml of acetone, and 10 ml of a solution of methanesulfonic acid in absolute ethanol is slowly added. The solid precipitated is filtered to give the title compound, which is dried at 55° C. under vacuum. Melting point: 181.6° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08501779B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-b78a8ef1cd6b42dbad2d3939f85950c9 |
| Source note | uspto-grants-2013_08 |