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HRID1888016

反应详情

EQUATION

反应方程式

HRID 1888016 的结构方程式

REACTANTS

反应物

2
结构：COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2
HCID3152

Donepezil

C24H29NO3

结构：CS(=O)(=O)O
HCID6395

Methanesulfonic acid

CH4O3S

PRODUCTS

生成物

1
结构：COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2.CS(=O)(=O)[O-]
HCID131730793

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CC(C)=O
溶剂HCID180

Acetone

C3H6O

结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

3.79 g of Donepezil is dissolved in 80 ml of acetone, and 10 ml of a solution of methanesulfonic acid in absolute ethanol is slowly added. The solid precipitated is filtered to give the title compound, which is dried at 55° C. under vacuum. Melting point: 181.6° C.

WORKUP

后处理

  1. customThe solid precipitated
  2. filtrationis filtered