Nitric Acid → HCID 86648415, compound

HRID 1888041Notes

Reaction equation

HRID 1888041 reaction equation
[N+:1]([O-:4])([OH:3])=[O:2].[CH3:5][O:6][C:7]1[CH:8]=[C:9]2[CH2:18][CH:17]([CH2:19][CH:20]3[CH2:25][CH2:24][N:23]([CH2:26][C:27]4[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=4)[CH2:22][CH2:21]3)[C:15](=[O:16])[C:10]2=[CH:11][C:12]=1[O:13][CH3:14]>C(OCC)(=O)C>[CH3:5][O:6][C:7]1[CH:8]=[C:9]2[CH2:18][CH:17]([CH2:19][CH:20]3[CH2:21][CH2:22][N:23]([CH2:26][C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=4)[CH2:24][CH2:25]3)[C:15](=[O:16])[C:10]2=[CH:11][C:12]=1[O:13][CH3:14].[N+:1]([O-:4])([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 3152Donepezil

Product 1

HCID 86648415HCID 86648415, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Nitric acid (0.45 ml, dissolved in 35 ml of acetone) is slowly added to a solution of Donepezil (3.79 g) in ethyl acetate (70 ml) with stirring at room temperature. The solid precipitated is filtered and dried at 55° C. under vacuum to give the title compound. Melting point: 212.8° C.

Workup

  1. customThe solid precipitated
  2. filtrationis filtered
  3. customdried at 55° C. under vacuum

Sources & evidence

ORD record
ord-ee187b03f654447c943956184955b36d
Source dataset
uspto-grants-2013_08
Patent number
US08501779B2

Reaction notes

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