反应详情

Maleic acid (1.161 g, dissolved in 35 ml of acetone) is slowly added to a solution of Donepezil (3.79 g) in ethyl acetate (70 ml) with stirring at room temperature. The mixture is stirred for 3 hours at room temperature and concentrated at vacuum to give the title compound.

1. stirringThe mixture is stirred for 3 hours at room temperature
2. concentrationconcentrated at vacuum