HuagongsheHuagongshe Chemistry Print Report · For research reference only
Donepezil → Donepezil Maleate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Donepezil | HCID 3152 | — |
| Reactant | Maleic Acid | HCID 444266 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Donepezil Maleate | HCID 24801486 | — |
Reaction Steps
Maleic acid (1.161 g, dissolved in 10 ml of acetone) is slowly added to a solution of Donepezil (3.79 g) in ethyl acetate (20 ml) with stirring at room temperature. The solid precipitated is filtered and dried at 55° C. under vacuum to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08501779B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-711eade08abb48a9b96081f3e20f5297 |
| Source note | uspto-grants-2013_08 |