反应详情

Maleic acid (1.161 g, dissolved in 10 ml of acetone) is slowly added to a solution of Donepezil (3.79 g) in ethyl acetate (20 ml) with stirring at room temperature. The solid precipitated is filtered and dried at 55° C. under vacuum to give the title compound.

1. customThe solid precipitated
2. filtrationis filtered
3. customdried at 55° C. under vacuum