HuagongsheHuagongshe Chemistry Print Report · For research reference only
Malonic Acid → HCID 86648419, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Malonic Acid | HCID 867 | — |
| Reactant | Donepezil | HCID 3152 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 86648419 | HCID 86648419 | — |
Reaction Steps
Malonic acid (1.18 g, dissolved in 35 ml of 2-propanol and 5 ml of water) is added slowly to a solution of Donepezil (3.79 g) in ethyl acetate (70 ml) with stirring at room temperature. The solid precipitated is filtered and dried at 55° C. under vacuum to give the title compound. Melting point: 165.7° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08501779B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-ebf65c233ca044a0a5337a8a056e0005 |
| Source note | uspto-grants-2013_08 |