Malonic Acid → HCID 86648419, compound

HRID 1888074Notes

Reaction equation

HRID 1888074 reaction equation
[C:1]([OH:7])(=[O:6])[CH2:2][C:3]([OH:5])=[O:4].[CH3:8][O:9][C:10]1[CH:11]=[C:12]2[CH2:21][CH:20]([CH2:22][CH:23]3[CH2:28][CH2:27][N:26]([CH2:29][C:30]4[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=4)[CH2:25][CH2:24]3)[C:18](=[O:19])[C:13]2=[CH:14][C:15]=1[O:16][CH3:17]>C(OCC)(=O)C>[CH3:8][O:9][C:10]1[CH:11]=[C:12]2[CH2:21][CH:20]([CH2:22][CH:23]3[CH2:24][CH2:25][N:26]([CH2:29][C:30]4[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=4)[CH2:27][CH2:28]3)[C:18](=[O:19])[C:13]2=[CH:14][C:15]=1[O:16][CH3:17].[C:1]([O-:7])(=[O:6])[CH2:2][C:3]([O-:5])=[O:4]

Participants

4

Reactant 2

HCID 867Malonic AcidHCID 3152Donepezil

Product 1

HCID 86648419HCID 86648419, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Malonic acid (1.18 g, dissolved in 35 ml of 2-propanol and 5 ml of water) is added slowly to a solution of Donepezil (3.79 g) in ethyl acetate (70 ml) with stirring at room temperature. The solid precipitated is filtered and dried at 55° C. under vacuum to give the title compound. Melting point: 165.7° C.

Workup

  1. customThe solid precipitated
  2. filtrationis filtered
  3. customdried at 55° C. under vacuum

Sources & evidence

ORD record
ord-ebf65c233ca044a0a5337a8a056e0005
Source dataset
uspto-grants-2013_08
Patent number
US08501779B2

Reaction notes

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