Potassium Carbonate → HCID 67119941, compound

HRID 1888079Notes

Reaction equation

HRID 1888079 reaction equation
[C:1]([CH2:9][C:10]1([OH:16])[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:17][C:18]1[CH:25]=[CH:24][C:21]([CH2:22]Br)=[CH:20][CH:19]=1.C([O-])([O-])=O.[K+].[K+]>CC(C)=O.[I-].[K+]>[ClH:17].[Cl:17][C:18]1[CH:25]=[CH:24][C:21]([CH2:22][N:13]2[CH2:14][CH2:15][C:10]([CH2:9][C:1](=[O:8])[C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)([OH:16])[CH2:11][CH2:12]2)=[CH:20][CH:19]=1

Participants

6

Reactant 3

HCID 11430Potassium CarbonateHCID 693291-(Bromomethyl)-4-chlorobenzeneHCID 67119951HCID 67119951, compound2×

Product 1

HCID 67119941HCID 67119941, compoundYield 70.5%

Reagents, catalysts & solvents 2

HCID 4875Potassium IodideCatalystHCID 180AcetoneSolvent

Procedure

4-benzoylmethyl-4-piperidinol (II) is firstly prepared according to the method of synthesis and post-treatment in General Method one. Thereafter, 1.76 g (8.8 mmol) of p-chlorobenzyl bromide and 1.75 g (8.0 mmol) of 4-benzoylmethyl-4-piperidinol (II), 0.03 g (0.2 mmol) of potassium iodide and 3.53 g (25.6 mmol) of anhydrous K2CO3 is placed in anhydrous acetone (60 ml), and reacting at reflux for 8 hours. Operating according to the post-treatment procedure in General Method two obtains 2.25 g of a white crystal, with yield of 70.5%.

Workup

  1. customaccording to the method of synthesis
  2. temperatureat reflux for 8 hours

Sources & evidence

ORD record
ord-691edbeb3df443ceb3ed6a61e1670b57
Source dataset
uspto-grants-2013_08
Patent number
US08501778B2

Reaction notes

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