反应详情

温度

60 °C

To ethyl 3-benzamido-2-methylbutanoate (0.08 g, 0.321 mmol) in MeOH (2 mL) and water (1.000 mL) was added lithium hydroxide (0.015 g, 0.642 mmol) at RT. Contents heated at 60° C. for 1.5 h. The reaction mixture was concentrated and partitioned between dichloromethane (10 mL) and 1N HCl (5 mL). The dichloromethane layer is washed with brine (10 mL), dried overt sodium sulfate and concentrated to yield the title compound (0.055 g, 0.249 mmol, 77% yield) as a foamy solid, which was used as such for the subsequent step without further purification. MS (ESI) m/z 222.16 (M+H)+.

1. concentrationThe reaction mixture was concentrated
2. custompartitioned between dichloromethane (10 mL) and 1N HCl (5 mL)
3. washThe dichloromethane layer is washed with brine (10 mL)
4. dry with materialdried overt sodium sulfate
5. concentrationconcentrated