Flunixin Meglumine → Flunixin

Participants

Reaction Steps

5 L of water is added to about 500 g of Banamine Granules while maintaining the temperature at less than 30° C. The resulting mixture was agitated for about 3 hours while continuing to maintain the temperature at less than 30° C. The solids were removed by filtration. The filtered solids were washed with about 1 L of water and the pH of the combined filtrates was adjusted to 4-5 with aqueous citric acid solution. The precipitated Flunixin was collected by filtration and washed with 0.5 L of water, then dried at about 50-60° C. to a moisture content of less than 1% to yield crude Flunixin.

Provenance & Evidence