Flunixin Meglumine → Flunixin

HRID 1888134Notes

Reaction equation

HRID 1888134 reaction equation
[CH3:1][C:2]1[C:7]([NH:8][C:9]2[N:14]=[CH:13][CH:12]=[CH:11][C:10]=2[C:15]([OH:17])=[O:16])=[CH:6][CH:5]=[CH:4][C:3]=1[C:18]([F:21])([F:20])[F:19].CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO>O>[CH3:1][C:2]1[C:7]([NH:8][C:9]2[N:14]=[CH:13][CH:12]=[CH:11][C:10]=2[C:15]([OH:17])=[O:16])=[CH:6][CH:5]=[CH:4][C:3]=1[C:18]([F:20])([F:19])[F:21]

Participants

3

Reactant 1

HCID 39212Flunixin Meglumine

Product 1

HCID 38081Flunixin

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

5 L of water is added to about 500 g of Banamine Granules while maintaining the temperature at less than 30° C. The resulting mixture was agitated for about 3 hours while continuing to maintain the temperature at less than 30° C. The solids were removed by filtration. The filtered solids were washed with about 1 L of water and the pH of the combined filtrates was adjusted to 4-5 with aqueous citric acid solution. The precipitated Flunixin was collected by filtration and washed with 0.5 L of water, then dried at about 50-60° C. to a moisture content of less than 1% to yield crude Flunixin.

Workup

  1. temperaturewhile maintaining the temperature at less than 30° C
  2. temperatureto maintain the temperature at less than 30° C
  3. customThe solids were removed by filtration
  4. washThe filtered solids were washed with about 1 L of water
  5. filtrationThe precipitated Flunixin was collected by filtration
  6. washwashed with 0.5 L of water
  7. customdried at about 50-60° C. to a moisture content of less than 1%

Sources & evidence

ORD record
ord-b0403fdb43aa46619e984170118959d1
Source dataset
uspto-grants-2013_08
Patent number
US08501788B2

Reaction notes

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