反应详情

To a stirred solution of 0.21 g (1.14 mmol) of methyl(4-methoxy-5-pyrimidinyl)acetate from Step A in 0.5 mL of water and 1.5 mL of ethanol was added 81 mg (1.9 mmol) of lithium hydroxide hydrate. The reaction mixture was stirred at ambient temperature for 2 h then concentrated in vacuo to remove all volatiles. The residue was diluted with 3 mL of 2.0 N aqueous hydrogen chloride and then concentrated in vacuo to remove all volatiles to yield the title compound as an off white solid (191 mg, 90%). 1H-NMR (500 MHz, CD3OD) δ: 8.72 (s, 1H), 8.35 (s, 1H), 4.01 (s, 3H), 3.57 (s,2H). LC-MS: m/z (E/S) 169 (MH)+.

1. concentrationthen concentrated in vacuo
2. customto remove all volatiles
3. additionThe residue was diluted with 3 mL of 2.0 N aqueous hydrogen chloride
4. concentrationconcentrated in vacuo
5. customto remove all volatiles