Trifluoroacetic acid → HCID 178509434, compound

HRID 1888211Notes

Reaction equation

HRID 1888211 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([C:11]#[N:12])[CH:10]=1)[NH:7][N:6]=[C:5]2[CH:13]1[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]1.FC(F)(F)C(O)=O>ClCCl>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([C:11]#[N:12])[CH:10]=1)[NH:7][N:6]=[C:5]2[CH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178451811HCID 178451811, compound2×

Product 1

HCID 178509434HCID 178509434, compoundYield 147.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 1,1-dimethylethyl 4-(5-bromo-7-cyano-1H-indazol-3-yl)-1-piperidine-carboxylate (Intermediate 3) (0.200 g, 0.493 mmols) and trifluoroacetic acid (0.25 mL) in dichloromethane (5 mL) was stirred at room temperature for 2 hrs. The solution was cooled and the solvent removed in vacuo to give the crude amine (222 mg) trifluoroacetate salt, which was used in the next step without further purification.

Workup

  1. temperatureThe solution was cooled
  2. customthe solvent removed in vacuo

Sources & evidence

ORD record
ord-fb808721c9014c93b9d0ec8234f112cf
Source dataset
uspto-grants-2013_08
Patent number
US08501780B2

Reaction notes

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