Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HCID 178477695, 화합물 → HCID 178477694, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | HCID 178477695 | HCID 178477695 | — |
| 촉매 | Manganese dioxide | HCID 14801 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | HCID 178477694 | HCID 178477694 | — |
반응 단계
To a solution of 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-[3-(hydroxymethyl)phenyl]-1H-indazole-7-carboxamide (Intermediate 23) (130 mg, 0.294 mmol) in THF (50 mL) was added MnO2 (900 mg, 8.8 mmol). The reaction mixture was stirred at room temperature overnight and filtered. The filtrate was concentrated at reduced pressure to give the crude title compound, which was used in the next step without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08501780B2 |
| 출처 데이터셋 | uspto-grants-2013_08 |
| ORD ID | ord-bf1020875a604530a53e9e5b08318098 |
| 출처 메모 | uspto-grants-2013_08 |