反应详情

温度

150 °C

The mixture of 5-amino-2-bromobenzoic acid methyl ester (14.27 g, 62.0 mmol) and CuCN (6.11 g, 68.2 mmol) in DMF (130 ml) was heated at 150° C. for 1 h 10 min under nitrogen atmosphere. The mixture was cooled to 70° C. and poured into the mixture of water (250 ml) and 12.5% NH3 (500 ml). The product was extracted into ethyl acetate (3×250 ml). The organic phase was washed several times with 12.5% NH3 and water, dried over Na2SO4 and concentrated under vacuum.

1. temperatureThe mixture was cooled to 70° C.
2. extractionThe product was extracted into ethyl acetate (3×250 ml)
3. washThe organic phase was washed several times with 12.5% NH3 and water
4. dry with materialdried over Na2SO4
5. concentrationconcentrated under vacuum