Hexanal → HCID 86626354, compound

HRID 1888675Notes

Reaction equation

HRID 1888675 reaction equation
Cl.[F:2][CH2:3][C:4]([CH3:7])([NH2:6])[CH3:5].S([O-])([O-])(=O)=O.[Mg+2].C(=O)([O-])[O-].[K+].[K+].[CH:20](=O)[CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]>ClCCl>[F:2][CH2:3][C:4]([CH3:7])([N:6]=[CH:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])[CH3:5]

Participants

6

Reactant 4

HCID 6184HexanalHCID 11430Potassium CarbonateHCID 24083Sulfuric acid magnesium salt (1:1)HCID 139352511-Fluoro-2-methylpropan-2-amine hydrochloride

Product 1

HCID 86626354HCID 86626354, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a suspension of 1-fluoro-2-methylpropan-2-amine hydrochloride (ABCR) (2 g, 15.7 mmol), anhydrous magnesium sulfate (3.77 g, 31.4 mmol) and potassium carbonate (2.17 g, 15.68 mmol) in dichloromethane (100 mL) was added drop wise hexanal (1.93 mL, 15.7 mmol) at 0° C. The reaction mixture was stirred for 10 h at room temperature, then filtered and concentrated to obtain the title compound as a pale yellow liquid.

Workup

  1. filtrationfiltered
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-b5f2092cadf84eb8a9d714f0f0ba33f2
Source dataset
uspto-grants-2013_08
Patent number
US08501794B2

Reaction notes

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