反应详情

温度

0 °C

A mixture of the product of Example 163 (220 mg, 0.6 mmol) in CH2Cl2 (20 mL) and triethylamine (181 mg, 1.8 mmol) was cooled to 0° C., and treated dropwise with methanesulfonyl chloride (102 mg, 0.9 mmol). The reaction was stirred at 0° C. for 30 min., poured into water, and the mixture was extracted with CH2Cl2 (2×). The organics were combined, dried over MgSO4, filtered and concentrated to afford the title compound (234 mg, 88%). MS (DCI/NH3) m/z 383 (M−Ms+15)+.

1. extractionthe mixture was extracted with CH2Cl2 (2×)
2. dry with materialdried over MgSO4
3. filtrationfiltered
4. concentrationconcentrated