Ethanolamine Hydrochloride → HCID 178441277, compound

HRID 1888696Notes

Reaction equation

[CH2:1]([C:5]1=[CH:6][N:7]([C:24]([CH3:27])([CH3:26])[CH3:25])[S:8]/[C:9]/1=[N:10]\[C:11]([C@:13]1([CH3:23])[CH2:17][CH2:16][C@H:15]([C:18]([OH:20])=O)[C:14]1([CH3:22])[CH3:21])=[O:12])[CH2:2][CH2:3][CH3:4].Cl.[CH2:29]([CH2:31][NH2:32])[OH:30]>>[CH2:1]([C:5]1=[CH:6][N:7]([C:24]([CH3:27])([CH3:26])[CH3:25])[S:8]/[C:9]/1=[N:10]\[C:11]([C@:13]1([CH3:23])[CH2:17][CH2:16][C@H:15]([C:18]([NH:32][CH2:31][CH2:29][OH:30])=[O:20])[C:14]1([CH3:21])[CH3:22])=[O:12])[CH2:2][CH2:3][CH3:4]

Participants

Reactant 2

HCID 74819Ethanolamine Hydrochloride

HCID 178441278HCID 178441278, compound

Product 1

HCID 178441277HCID 178441277, compound

Procedure

The product from Example 173 and ethanolamine hydrochloride (Aldrich) were processed using the method described in Example 178 to afford the title compound. 1H NMR (DMSO-d6) δ 0.47 (s, 3H), 0.90 (t. J=7.0 Hz, 3H), 1.19 (s, 3H), 1.23 (s, 3H), 1.26-1.48 (m, 4H), 1.57 (s, 9H), 1.57-1.67 (m, 3H), 1.96-2.08 (m, 1H), 2.62-2.68 (m, 2H), 2.71-2.82 (m, 1H), 3.00-3.10 (m, 1H), 3.14-2.25 (m, 1H), 3.33-3.39 (m, 2H), 4.62 (t, J=4.6 Hz, 1H), 7.52 (t, J=5.7 Hz, 1H), 8.50 (s, 1H). MS (ESI+) m/z 438 (M+H)+.

Sources & evidence

ORD record: ord-ca183050c32547fd9c184d746f491dd3
Source dataset: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08501794B2

Reaction notes

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