2-Ethylhexyl 3-mercaptopropionate → 2-Ethylhexyl 3-{[5-(benzyloxy)-2-nitrophenyl]sulfanyl}propanoate

HRID 1888732Notes

Reaction equation

HRID 1888732 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[C:11](F)[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[SH:19][CH2:20][CH2:21][C:22]([O:24][CH2:25][CH:26]([CH2:31][CH3:32])[CH2:27][CH2:28][CH2:29][CH3:30])=[O:23]>>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[C:11]([S:19][CH2:20][CH2:21][C:22]([O:24][CH2:25][CH:26]([CH2:31][CH3:32])[CH2:27][CH2:28][CH2:29][CH3:30])=[O:23])[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 926402-Ethylhexyl 3-mercaptopropionateHCID 221807044-Benzyloxy-2-fluoro-1-nitrobenzene

Product 1

HCID 580473802-Ethylhexyl 3-{[5-(benzyloxy)-2-nitrophenyl]sulfanyl}propanoateYield 100.3%

Procedure

Using 4-(benzyloxy)-2-fluoro-1-nitrobenzene (10.3 g, 41.6 mmol) and 2-ethylhexyl 3-sulfanylpropanoate (10.0 g, 45.8 mmol) and in the same manner as in Reference Example 81, the title compound (18.6 g, quantitative) was obtained as an oil.

Sources & evidence

ORD record
ord-46b8181a774b4598b66b3d025758d817
Source dataset
uspto-grants-2013_08
Patent number
US08501804B2

Reaction notes

Loading…