2-N-Boc-aminopropionic acid → HCID 70228130, compound

HRID 1888733Notes

Reaction equation

HRID 1888733 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[OH:10].[C:11]([O:15][C:16]([NH:18][CH:19]([C:21](O)=[O:22])[CH3:20])=[O:17])([CH3:14])([CH3:13])[CH3:12]>>[OH:10][C:3]1[CH:4]=[CH:5][C:6]([O:8][CH3:9])=[CH:7][C:2]=1[NH:1][C:21](=[O:22])[CH:19]([NH:18][C:16](=[O:17])[O:15][C:11]([CH3:13])([CH3:12])[CH3:14])[CH3:20]

Participants

3

Reactant 2

HCID 2684712-N-Boc-aminopropionic acidHCID 14191082-Amino-4-methoxyphenol

Product 1

HCID 70228130HCID 70228130, compoundYield 81%

Procedure

Using 2-amino-4-methoxyphenol (3.00 g, 21.6 mmol) and N-(tert-butoxycarbonyl)-D,L-alanine (4.08 g, 21.6 mmol), a method in the same manner as in Reference Example 13 was performed, and the obtained residue was triturated with ethyl acetate to give the title compound (5.42 g, yield 81%).

Workup

  1. customthe obtained residue was triturated with ethyl acetate

Sources & evidence

ORD record
ord-53392665b3f441b29d2647e4094af439
Source dataset
uspto-grants-2013_08
Patent number
US08501804B2

Reaction notes

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