(2R)-oxolan-2-ylmethanol → HCID 58047354, compound

HRID 1888761Notes

Reaction equation

HRID 1888761 reaction equation
[O:1]1[CH2:5][CH2:4][CH2:3][C@@H:2]1[CH2:6][OH:7].[F:8][C:9]1[CH:18]=[C:17](O)[CH:16]=[CH:15][C:10]=1[C:11]([O:13][CH3:14])=[O:12]>>[F:8][C:9]1[CH:18]=[C:17]([O:7][CH2:6][C@H:2]2[CH2:3][CH2:4][CH2:5][O:1]2)[CH:16]=[CH:15][C:10]=1[C:11]([O:13][CH3:14])=[O:12]

Participants

3

Reactant 2

HCID 6931745(2R)-oxolan-2-ylmethanolHCID 22463192Methyl 2-fluoro-4-hydroxybenzoate

Product 1

HCID 58047354HCID 58047354, compoundYield 98%

Procedure

Using (2R)-tetrahydrofuran-2-ylmethanol (1.71 g, 10.0 mmol) and methyl 2-fluoro-4-hydroxybenzoate (1.24 g, 12.0 mmol) obtained in Reference Example 272 and in the same manner as in Reference Example 273, the title compound (2.49 g, yield 98%) was obtained as colorless crystals.

Workup

  1. customobtained in Reference Example 272 and in the same manner as in Reference Example 273

Sources & evidence

ORD record
ord-51e50d5372654f2ca78ca78065d58864
Source dataset
uspto-grants-2013_08
Patent number
US08501804B2

Reaction notes

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