Sodium Hydroxide → HCID 58047222, compound

HRID 1888771Notes

Reaction equation

HRID 1888771 reaction equation
[CH2:1]([O:3][C:4]1[CH:32]=[CH:31][C:7]([CH2:8][O:9][C:10]2[CH:11]=[CH:12][C:13]3[O:17][C:16]([CH:18]([NH:20][C:21](=[O:29])[CH2:22][CH2:23][CH2:24][C:25]([O:27]C)=[O:26])[CH3:19])=[CH:15][C:14]=3[CH:30]=2)=[CH:6][CH:5]=1)[CH3:2].[OH-].[Na+]>CO>[CH2:1]([O:3][C:4]1[CH:5]=[CH:6][C:7]([CH2:8][O:9][C:10]2[CH:11]=[CH:12][C:13]3[O:17][C:16]([CH:18]([NH:20][C:21](=[O:29])[CH2:22][CH2:23][CH2:24][C:25]([OH:27])=[O:26])[CH3:19])=[CH:15][C:14]=3[CH:30]=2)=[CH:31][CH:32]=1)[CH3:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 58047460HCID 58047460, compound

Product 1

HCID 58047222HCID 58047222, compoundYield 30%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using methyl 5-[(1-{5-[(4-ethoxybenzyl)oxy]-1-benzofuran-2-yl}ethyl)amino]-5-oxopentanoate (214 mg, 0.489 mmol) obtained in Example 97, methanol (2.0 mL) and 8N aqueous sodium hydroxide solution (0.10 mL, 0.82 mmol), an operation in the same manner as in Example 35 was performed to give the title compound (10.2 mg, yield 30%) as a white solid.

Sources & evidence

ORD record
ord-779021ee977749778e2fc410919e35e2
Source dataset
uspto-grants-2013_08
Patent number
US08501804B2

Reaction notes

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