Bromomethylcyclopropane → HCID 58047437, compound

HRID 1888775Notes

Reaction equation

[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]2[CH:11]=[CH:12][C:13]3[O:17][C:16]([CH:18]([NH:20][C:21](=[O:23])[CH3:22])[CH3:19])=[CH:15][C:14]=3[CH:24]=2)=[CH:4][CH:3]=1.Br[CH2:26][CH:27]1[CH2:29][CH2:28]1>>[CH:27]1([CH2:26][O:1][C:2]2[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]3[CH:11]=[CH:12][C:13]4[O:17][C:16]([CH:18]([NH:20][C:21](=[O:23])[CH3:22])[CH3:19])=[CH:15][C:14]=4[CH:24]=3)=[CH:4][CH:3]=2)[CH2:29][CH2:28]1

Participants

Reactant 2

HCID 81503Bromomethylcyclopropane

HCID 58047066HCID 58047066, compound

Product 1

HCID 58047437HCID 58047437, compoundYield 32%

Procedure

Using N-(1-{5-[2-(4-hydroxyphenyl)ethyl]-1-benzofuran-2-yl}ethyl)acetamide (328 mg, 1.01 mmol) obtained in Example 157 and (bromomethyl)cyclopropane (3.97 g, 29.3 mmol) and in the same manner as in Example 158, the title compound was obtained (122 mg, yield 32%) as colorless crystals.

Sources & evidence

ORD record: ord-c2b9201182714f8582c33040f663e992
Source dataset: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08501804B2

Reaction notes

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