Butyl bromide → HCID 58047502, compound

HRID 1888776Notes

Reaction equation

[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]2[CH:11]=[CH:12][C:13]3[O:17][C:16]([CH:18]([NH:20][C:21](=[O:23])[CH3:22])[CH3:19])=[CH:15][C:14]=3[CH:24]=2)=[CH:4][CH:3]=1.Br[CH2:26][CH2:27][CH2:28][CH3:29]>>[CH2:26]([O:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]2[CH:11]=[CH:12][C:13]3[O:17][C:16]([CH:18]([NH:20][C:21](=[O:23])[CH3:22])[CH3:19])=[CH:15][C:14]=3[CH:24]=2)=[CH:4][CH:3]=1)[CH2:27][CH2:28][CH3:29]

Participants

Reactant 2

HCID 8002Butyl bromide

HCID 58047066HCID 58047066, compound

Product 1

HCID 58047502HCID 58047502, compoundYield 66%

Procedure

Using N-(1-{5-[2-(4-hydroxyphenyl)ethyl]-1-benzofuran-2-yl}ethyl)acetamide (124 mg, 0.348 mmol) obtained in Example 157 and bromobutane (263 mg, 1.92 mmol) and in the same manner as in Example 158, the title compound was obtained (96.3 mg, yield 66%) as colorless crystals.

Sources & evidence

ORD record: ord-c3e9aff066e14ff5b4f235861e1b43bb
Source dataset: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08501804B2

Reaction notes

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