2-Chloroethyl methyl sulfide → HCID 58047280, compound

HRID 1888780Notes

Reaction equation

HRID 1888780 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]2[CH:24]=[CH:23][C:13]3[CH:14]=[C:15]([CH:17]([NH:19][C:20](=[O:22])[CH3:21])[CH3:18])[O:16][C:12]=3[CH:11]=2)=[CH:4][CH:3]=1.Cl[CH2:26][CH2:27][S:28][CH3:29]>>[CH3:29][S:28][CH2:27][CH2:26][O:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][C:10]2[CH:24]=[CH:23][C:13]3[CH:14]=[C:15]([CH:17]([NH:19][C:20](=[O:22])[CH3:21])[CH3:18])[O:16][C:12]=3[CH:11]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 109652-Chloroethyl methyl sulfideHCID 58047041HCID 58047041, compound

Product 1

HCID 58047280HCID 58047280, compoundYield 50%

Procedure

Using N-(1-{6-[2-(4-hydroxyphenyl)ethyl]-1-benzofuran-2-yl}ethyl)acetamide (150 mg, 0.464 mmol) obtained in Example 165 and 2-chloroethylmethylsulfide (0.182 mL, 1.86 mmol) and in the same manner as in Example 158, the title compound was obtained (91.9 mg, yield 50%) as a white solid.

Sources & evidence

ORD record
ord-304c560b98114bcf87ee5c7bc9c847ea
Source dataset
uspto-grants-2013_08
Patent number
US08501804B2

Reaction notes

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