HCID 54577999, compound → Saxagliptin Hydrate

HRID 1888968Notes

Reaction equation

HRID 1888968 reaction equation
CC(=[N:4][C@@H:5]([C:16]12[CH2:25][CH:20]3[CH2:21][CH:22]([CH2:24][C:18]([OH:26])([CH2:19]3)[CH2:17]1)[CH2:23]2)[C:6]([N:8]1[C@H:13]([C:14]#[N:15])[CH2:12][C@H:11]2[C@@H:9]1[CH2:10]2)=[O:7])C>O>[CH2:12]1[C@@H:13]([C:14]#[N:15])[N:8]([C:6]([C@@H:5]([NH2:4])[C:16]23[CH2:17][C:18]4([OH:26])[CH2:24][CH:22]([CH2:21][CH:20]([CH2:19]4)[CH2:25]2)[CH2:23]3)=[O:7])[C@@H:9]2[C@H:11]1[CH2:10]2.[OH2:7]

Participants

3

Reactant 1

HCID 54577999HCID 54577999, compound

Product 1

HCID 53297473Saxagliptin HydrateYield 80.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The Schiff base (Compound M, 7.27 g) was suspended in 25 ml of water. The obtained suspension was stirred overnight at room temperature in a closed flask. The product was filtered off and dried at 40° C./0 mbar for 2 hours. (Yield=80.1%) HPLC 100%, Powder XRD—H-1

Workup

  1. filtrationThe product was filtered off
  2. customdried at 40° C./0 mbar for 2 hours

Sources & evidence

ORD record
ord-46d92c5e6b264fd7a7d91d3fa5859288
Source dataset
uspto-grants-2013_08
Patent number
US08501960B2

Reaction notes

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