反应详情

The Schiff base of Saxagliptin (compound M, 500 mg) was dissolved in acetone (4 ml), and HCl (0.131 ml, 36.5%) was added. The resulting suspension was stirred for 30 min. Water (0.6 ml) was added and continued stirring for additional 45 min. The suspension was then filtered yielding saxagliptin hydrochloride, form H2-1 (375 mg).

1. stirringcontinued stirring for additional 45 min
2. filtrationThe suspension was then filtered