Hydrochloric Acid → 3-[(Furan-2-carbonyl)-amino]-3-{3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-4,5-dihydro-isoxazol-5-yl}-propionic acid methyl ester

HRID 188903Notes

Reaction equation

HRID 188903 reaction equation
[CH2:48]([Cl:49])[Cl:50].[CH3:11][O:12][C:13]([CH2:14][CH:15]([CH:16]1[CH2:17][C:18]([c:21]2[cH:22][cH:23][c:24]([O:27][CH2:28][c:29]3[cH:30][c:31]([CH3:39])[n:32][c:33]4[cH:34][cH:35][cH:36][cH:37][c:38]34)[cH:25][cH:26]2)=[N:19][O:20]1)[NH2:40])=[O:41].[ClH:10].[ClH:9].[Na+:42].[Na+:43].[O-:44][C:45](=[O:46])[O-:47].[o:1]1[c:2]([C:6](=[O:7])[Cl:8])[cH:3][cH:4][cH:5]1>>[o:1]1[c:2]([C:6](=[O:7])[NH:40][CH:15]([CH2:14][C:13]([O:12][CH3:11])=[O:41])[CH:16]2[CH2:17][C:18]([c:21]3[cH:22][cH:23][c:24]([O:27][CH2:28][c:29]4[cH:30][c:31]([CH3:39])[n:32][c:33]5[cH:34][cH:35][cH:36][cH:37][c:38]45)[cH:25][cH:26]3)=[N:19][O:20]2)[cH:3][cH:4][cH:5]1

Participants

7

Reactant 6

HCID 313Hydrochloric Acid2×HCID 923Sodium ion2×HCID 6344DichloromethaneHCID 19660Carbonate IonHCID 682422-Furancarbonyl chlorideHCID 69639746Methyl 3-amino-3-[3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-4,5-dihydro-1,2-oxazol-5-yl]propanoate

Product 1

HCID 696401143-[(Furan-2-carbonyl)-amino]-3-{3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-4,5-dihydro-isoxazol-5-yl}-propionic acid methyl ester

Sources & evidence

ORD record
ord-156b17e4760f4cb49b7e346e5d7c9e6a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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