Hydrazine hydrate (1:1) → HCID 178428523, compound

HRID 1889036Notes

Reaction equation

HRID 1889036 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]#[N:9])[N:3]=1.O.[NH2:11][NH2:12]>C(O)C>[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8](=[NH:9])[NH:11][NH2:12])[N:3]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 126843244-Methylpyrimidine-2-carbonitrile

Product 1

HCID 178428523HCID 178428523, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4-methyl-2-pyrimidinecarbonitrile (I98)(0.190 g, 1.595 mmol) was dissolved in ethanol (3.19 ml) and hydrazine hydrate (0.100 ml, 3.19 mmol) was added. The reaction mixture was left at reflux for 2.5 hours. TLC showed that no starting material remained so the solvent was removed under reduced pressure to afford the crude desired product in 247 mg.

Workup

  1. waitThe reaction mixture was left
  2. temperatureat reflux for 2.5 hours
  3. customwas removed under reduced pressure

Sources & evidence

ORD record
ord-1e337ac954234acbb6d2f95036a7e422
Source dataset
uspto-grants-2013_08
Patent number
US08501946B2

Reaction notes

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