Hydrochloric Acid → 3-(1H-Pyrazol-1-yl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine

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Reaction Steps

A mixture of 1,1-dimethylethyl 3-(1H-pyrazol-1-yl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate (I106) (24 mg, 0.083 mmol) and HCl (2 ml, 8.00 mmol) was stirred at room temp for 40 mins. The solvent was evaporated and the product was passed through SCX (elution with 2 M NH3 in methanol) to give the desired product as a white solid.

Provenance & Evidence