Hydrochloric Acid → 3-(1H-Pyrazol-1-yl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine

HRID 1889040Notes

Reaction equation

HRID 1889040 reaction equation
[N:1]1([C:6]2[N:10]3[CH2:11][CH2:12][N:13](C(OC(C)(C)C)=O)[CH2:14][C:9]3=[N:8][N:7]=2)[CH:5]=[CH:4][CH:3]=[N:2]1.Cl>>[N:1]1([C:6]2[N:10]3[CH2:11][CH2:12][NH:13][CH2:14][C:9]3=[N:8][N:7]=2)[CH:5]=[CH:4][CH:3]=[N:2]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 66599064HCID 66599064, compound

Product 1

HCID 665989553-(1H-Pyrazol-1-yl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine

Procedure

A mixture of 1,1-dimethylethyl 3-(1H-pyrazol-1-yl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate (I106) (24 mg, 0.083 mmol) and HCl (2 ml, 8.00 mmol) was stirred at room temp for 40 mins. The solvent was evaporated and the product was passed through SCX (elution with 2 M NH3 in methanol) to give the desired product as a white solid.

Workup

  1. customThe solvent was evaporated
  2. washthe product was passed through SCX (elution with 2 M NH3 in methanol)

Sources & evidence

ORD record
ord-85ce28f9bc0b4632833f3a346ca26bb3
Source dataset
uspto-grants-2013_08
Patent number
US08501946B2

Reaction notes

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