Hydrochloric Acid → HCID 1382089, compound

HRID 1889047Notes

Reaction equation

HRID 1889047 reaction equation
Cl.[S:2]1[N:6]=[CH:5][C:4]([C:7]([NH:9][NH:10]C(OC(C)(C)C)=O)=[O:8])=[N:3]1>O1CCOCC1>[S:2]1[N:6]=[CH:5][C:4]([C:7]([NH:9][NH2:10])=[O:8])=[N:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66599184HCID 66599184, compound

Product 1

HCID 1382089HCID 1382089, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

4M HCl (6.60 ml, 26.4 mmol) in 1,4-dioxane was added to 1,1-dimethylethyl 2-(1,2,5-thiadiazol-3-ylcarbonyl)hydrazinecarboxylate (I118) (1.29 g, 5.28 mmol). The reaction mixture was stirred at room temperature for 7 h. The solvent was evaporated under reduced pressure. The crude product was purified by SCX cartridge (2 batches of 500 mg each—MeOH/2M NH3 in MeOH to afford the desired product in 361.4 mg as a white powder.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customThe crude product was purified by SCX cartridge (2 batches of 500 mg each—MeOH/2M NH3 in MeOH

Sources & evidence

ORD record
ord-95abf7dd51154865892763627d978d1a
Source dataset
uspto-grants-2013_08
Patent number
US08501946B2

Reaction notes

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