10-Bromodecanoic Acid → 10-Azidodecanoic acid

HRID 1889148Notes

Reaction equation

HRID 1889148 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12].[N:14](CCCCCCCCC(O)=O)=[N+:15]=[N-:16]>>[N:14]([CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])=[N+:15]=[N-:16]

Participants

3

Reactant 2

HCID 14271210-Bromodecanoic AcidHCID 152305499-Azidononanoic acid

Product 1

HCID 8571414410-Azidodecanoic acidYield 91%

Procedure

10-bromodecanoic acid (1.125 gr, 4.48 mmol) was reacted as described for product 5a to yield 91% of product 5b. 1H-NMR (200 MHz, CDCl3): 1.2-1.5 (m; 10H), 1.5-1.7 (m; 4H), 2.35 (t; J=7.41 Hz; 2H), 3.24 (t; J=6.81 Hz; 2H).

Sources & evidence

ORD record
ord-c8b9509ab73e4d29b28c94e1bc43e34b
Source dataset
uspto-grants-2013_08
Patent number
US08501969B2

Reaction notes

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