Ammonium Hydroxide → 10-Aminodecanoic acid

HRID 1889151Notes

Reaction equation

Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12].[OH-].[NH4+:15]>>[NH2:15][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12]

Participants

Reactant 2

HCID 14923Ammonium Hydroxide

HCID 14271210-Bromodecanoic Acid

Product 1

HCID 8315010-Aminodecanoic acid

Procedure

10-bromodecanoic acid (2.51 gr, 10 mmol) was added to a round bottom flask containing 80 mL of aqueous ammonium hydroxide (25% NH3). The resulting mixture was stirred for 24 hours at room temperature, after which the aqueous solution was evaporated under reduced pressure, resulting in 8b as a white solid at quantitative yield. 1H-NMR (200 MHz, CD3OD): 1.25-1.4 (m; 10H), 1.5-1.7 (m; 4H), 2.15 (t; J=7.38 Hz; 2H), 2.89 (t; J=7.48 Hz; 2H).

Workup

customafter which the aqueous solution was evaporated under reduced pressure

Sources & evidence

ORD record: ord-63d3414b71e7467ab717e673f9905b5e
Source dataset: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08501969B2

Reaction notes

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