HRID1889223

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

结构：CC(C)(C)OC(=O)NCCCCCC(=O)Nc1ccc(NC(=S)NC(=O)c2ccc(C(C)(C)C)cc2)cc1

HCID86650281

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)c1ccc(C(=O)NC(=S)Nc2ccc(NC(=O)CCCCCN)cc2)cc1.O=C(O)C(F)(F)F

HCID86650282

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

Boc protected amine 32 (20 mg, 0.04 mmol) was stirred in CH2Cl2 (1 mL) and trifluoroacetic acid (166 μL) at rt for 30 min. Concentration in vacuo gave 33 as a pale yellow oil.

WORKUP

后处理

concentrationConcentration in vacuo

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-cb8c1ca72b5d474ea8faab82fe9fd046
来源数据集: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08501991B2
来源说明: uspto-grants-2013_08

反应 SMILES

C(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13](=[O:37])[NH:14][C:15]1[CH:20]=[CH:19][C:18]([NH:21][C:22]([NH:24][C:25](=[O:36])[C:26]2[CH:31]=[CH:30][C:29]([C:32]([CH3:35])([CH3:34])[CH3:33])=[CH:28][CH:27]=2)=[S:23])=[CH:17][CH:16]=1)(C)(C)C.[F:39][C:40]([F:45])([F:44])[C:41]([OH:43])=[O:42]>C(Cl)Cl>[F:39][C:40]([F:45])([F:44])[C:41]([OH:43])=[O:42].[C:32]([C:29]1[CH:28]=[CH:27][C:26]([C:25]([NH:24][C:22](=[S:23])[NH:21][C:18]2[CH:19]=[CH:20][C:15]([NH:14][C:13](=[O:37])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][NH2:7])=[CH:16][CH:17]=2)=[O:36])=[CH:31][CH:30]=1)([CH3:35])([CH3:33])[CH3:34]