Trifluoroacetic acid → 6-Amino-hexanoic acid {4-[3-(4-tert-butyl-benzoyl)-thioureido]-phenyl}-amide trifluoroacetate

HRID 1889223Notes

Reaction equation

HRID 1889223 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13](=[O:37])[NH:14][C:15]1[CH:20]=[CH:19][C:18]([NH:21][C:22]([NH:24][C:25](=[O:36])[C:26]2[CH:31]=[CH:30][C:29]([C:32]([CH3:35])([CH3:34])[CH3:33])=[CH:28][CH:27]=2)=[S:23])=[CH:17][CH:16]=1)(C)(C)C.[F:39][C:40]([F:45])([F:44])[C:41]([OH:43])=[O:42]>C(Cl)Cl>[F:39][C:40]([F:45])([F:44])[C:41]([OH:43])=[O:42].[C:32]([C:29]1[CH:28]=[CH:27][C:26]([C:25]([NH:24][C:22](=[S:23])[NH:21][C:18]2[CH:19]=[CH:20][C:15]([NH:14][C:13](=[O:37])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][NH2:7])=[CH:16][CH:17]=2)=[O:36])=[CH:31][CH:30]=1)([CH3:35])([CH3:33])[CH3:34]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86650281HCID 86650281, compound

Product 1

HCID 866502826-Amino-hexanoic acid {4-[3-(4-tert-butyl-benzoyl)-thioureido]-phenyl}-amide trifluoroacetate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Boc protected amine 32 (20 mg, 0.04 mmol) was stirred in CH2Cl2 (1 mL) and trifluoroacetic acid (166 μL) at rt for 30 min. Concentration in vacuo gave 33 as a pale yellow oil.

Workup

  1. concentrationConcentration in vacuo

Sources & evidence

ORD record
ord-cb8c1ca72b5d474ea8faab82fe9fd046
Source dataset
uspto-grants-2013_08
Patent number
US08501991B2

Reaction notes

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