反应详情

A solution of the product of step A) (18.7 g, 53.1 mmol) in toluene (40 mL) and THF (40 mL) was added to a Parr shaker bottle containing Pt2O (370 mg). This mixture was shaken under H2 (50 psi, 344.74 kpa) until the reaction was complete (18 h). The catalyst was removed by filtration, and the filtrate was concentrated to an oil. Column chromatography (1 kg silica gel packed in and eluted with CH2Cl2/MeOH, 19:1) gave 11.9 g (69.6%) of the title compound.

1. custom(18 h)
2. customThe catalyst was removed by filtration
3. concentrationthe filtrate was concentrated to an oil
4. washColumn chromatography (1 kg silica gel packed in and eluted with CH2Cl2/MeOH, 19:1)