HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1889247Generated: October 31, 2026
Tert-Butyl nitrite → 1,3-Dibromo-2,5-dichlorobenzene
https://huagongshe.com/reaction/1889247
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tert-Butyl nitrite | HCID 10906 | — |
| Reactant | 2,4-Dibromo-3,6-dichloroaniline | HCID 262511 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1,3-Dibromo-2,5-dichlorobenzene | HCID 14029667 | — |
Reaction Steps
A stirred mixture of 2,4-dibromo-3,6-dichloroaniline (5.0 g), tert-Butyl nitrite (3.3 g) and EtOH (50 mL) was heated in a sealed tube at 50° C. for 2 hrs. The mixture was concentrated and the residue was purified by silica gel flash chromatography (hexanes eluant) to afford the title compound. MS m/z: 303 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08501758B2 |
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| Source dataset | uspto-grants-2013_08 |
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| ORD ID | ord-fc2264d5c6d24438b4c9c1f0b2f02322 |
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| Source note | uspto-grants-2013_08 |
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