Tert-Butyl nitrite → 1,3-Dibromo-2,5-dichlorobenzene
Reaction equation
[Br:1][C:2]1[C:8]([Cl:9])=[C:7]([Br:10])[CH:6]=[C:5]([Cl:11])[C:3]=1N.N(OC(C)(C)C)=O>CCO>[Br:1][C:2]1[CH:3]=[C:5]([Cl:11])[CH:6]=[C:7]([Br:10])[C:8]=1[Cl:9]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 50 °C
Procedure
A stirred mixture of 2,4-dibromo-3,6-dichloroaniline (5.0 g), tert-Butyl nitrite (3.3 g) and EtOH (50 mL) was heated in a sealed tube at 50° C. for 2 hrs. The mixture was concentrated and the residue was purified by silica gel flash chromatography (hexanes eluant) to afford the title compound. MS m/z: 303 (M+H)+.
Workup
- concentrationThe mixture was concentrated
- customthe residue was purified by silica gel flash chromatography (hexanes eluant)
Sources & evidence
- ORD record
- ord-fc2264d5c6d24438b4c9c1f0b2f02322
- Source dataset
- uspto-grants-2013_08
- Patent number
- US08501758B2
Reaction notes
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