反应详情

To 9.60 g of 1-(2-phenoxy-ethoxy)-naphthalene-2-carboxylic acid methyl ester in 105 ml of THF were added 30 ml of 2 M aqueous sodium hydroxide and 40 ml of methanol. After 3 h at reflux the organic solvents were removed in vacuo. The residue was treated with 2 M hydrochloric acid, and three times extracted with ethyl acetate. The combined organic layers were dried over magnesium sulphate, and concentrated and dried in vacuo to yield 7.62 g of 1-(2-phenoxy-ethoxy)-naphthalene-2-carboxylic acid.

1. temperatureAfter 3 h at reflux the organic solvents
2. customwere removed in vacuo
3. additionThe residue was treated with 2 M hydrochloric acid, and three times
4. extractionextracted with ethyl acetate
5. dry with materialThe combined organic layers were dried over magnesium sulphate
6. concentrationconcentrated
7. customdried in vacuo