反应详情

To 0.47 g of 1-(1-methyl-2-phenoxy-ethoxy)-naphthalene-2-carboxylic acid methyl ester in 5 ml of THF and 2 ml methanol were added 10 ml of 2 M aqueous sodium hydroxide. After 16 h at room temperature and 2 h at reflux the organic solvents were removed in vacuo. The residue was treated with 2 M hydrochloric acid, and three times extracted with ethyl acetate. The combined organic layers were washed with brine, dried over magnesium sulphate, concentrated and dried in vacuo to yield 0.36 g of 1-(1-methyl-2-phenoxy-ethoxy)-naphthalene-2-carboxylic acid.

1. temperature2 h at reflux the organic solvents
2. customwere removed in vacuo
3. additionThe residue was treated with 2 M hydrochloric acid, and three times
4. extractionextracted with ethyl acetate
5. washThe combined organic layers were washed with brine
6. dry with materialdried over magnesium sulphate
7. concentrationconcentrated
8. customdried in vacuo