HCID 68840871, compound → HCID 68844805, compound

HRID 1889283Notes

Reaction equation

HRID 1889283 reaction equation
[CH3:1][O:2][C:3](=[O:30])[C:4]([CH3:29])([NH:6][C:7]([C:9]1[CH:18]=[CH:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]=1[C:19]#[C:20][CH2:21][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[O:8])[CH3:5]>CO.[Pd]>[CH3:1][O:2][C:3](=[O:30])[C:4]([CH3:5])([NH:6][C:7]([C:9]1[CH:18]=[CH:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]=1[CH2:19][CH2:20][CH2:21][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[O:8])[CH3:29]

Participants

4

Reactant 1

HCID 68840871HCID 68840871, compound

Product 1

HCID 68844805HCID 68844805, compoundYield 95%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

50 mg of 2-methyl-2-{[1-(4-phenyl-but-1-ynyl)-naphthalene-2-carbonyl]-amino}-propionic acid methyl ester were dissolved in 5 ml methanol, and after addition of 10 mg of Pd/C (10%) hydrogenated for 6 h. The reaction was then filtrated and the filtrate was concentrated to yield 48 mg of 2-methyl-2-{[1-(4-phenyl-butyl)-naphthalene-2-carbonyl]-amino}-propionic acid methyl ester.

Workup

  1. filtrationThe reaction was then filtrated
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-fffbd8c336d243c3b1acc2ac55279c1f
Source dataset
uspto-grants-2013_08
Patent number
US08501981B2

Reaction notes

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