反应详情

温度

50 °C

A mixture of 4′-{[3-(2,4-dimethoxybenzyl)-6-ethyl-2,4-dioxo-3,4-dihydrothieno[2,3-d]pyrimidin-1(2H)-yl]methyl}biphenyl-2-carbonitrile (64 g) and trifluoroacetic acid (300 mL) was stirred at 50° C. for 2 hr. To the reaction mixture was added toluene (300 mL), and the mixture was concentrated under reduced pressure. To the obtained residue was added ethyl acetate (150 mL), and the mixture was concentrated under reduced pressure. The precipitated solid was collected by filtration to give the title compound as a colorless solid (46.1 g, 100%).

1. concentrationthe mixture was concentrated under reduced pressure
2. additionTo the obtained residue was added ethyl acetate (150 mL)
3. concentrationthe mixture was concentrated under reduced pressure
4. filtrationThe precipitated solid was collected by filtration