HCID 59351564, compound → HCID 59351494, compound

HRID 1889416Notes

Reaction equation

HRID 1889416 reaction equation
[C:1]1([CH2:7][CH2:8][N:9]2[C:18](=[O:19])[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([CH:20]=[CH2:21])[CH:16]=3)[NH:11][C:10]2=[O:22])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>O1CCCC1CO.[C].[Pd]>[CH2:20]([C:15]1[CH:16]=[C:17]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10](=[O:22])[N:9]([CH2:8][CH2:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[C:18]2=[O:19])[CH3:21]

Participants

4

Reactant 1

HCID 59351564HCID 59351564, compound

Product 1

HCID 59351494HCID 59351494, compoundYield 78%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 7360Tetrahydrofurfuryl alcoholSolvent

Procedure

To a solution (20 mL) of 3-(2-phenylethyl)-6-vinylquinazoline-2,4(1H,3H)-dione (0.6 g) in tetrahydrofuran-methanol (1:1) was added palladium carbon (10%, 0.06 g), and the mixture was stirred under hydrogen atmosphere for 4 hr. Insoluble material was filtered off, and the filtrate was concentrated to give the title compound as a brown solid (0.47 g, 78%).

Workup

  1. filtrationInsoluble material was filtered off
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-96f698878ed341e287926045708611b4
Source dataset
uspto-grants-2013_08
Patent number
US08501750B2

Reaction notes

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