HRID1889429

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

HCID21840371

未命名化合物

结构：CCc1cc2c(=O)n(Cc3ccc(OC)cc3OC)c(=O)[nH]c2s1

HCID59351775

未命名化合物

PRODUCTS

生成物

结构：CCc1cc2c(=O)n(Cc3ccc(OC)cc3OC)c(=O)n(Cc3ccc(-c4ccccc4C#N)cc3Br)c2s1

HCID59351626

未命名化合物

收率 81.3%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6342

Acetonitrile

C2H3N

CONDITIONS

反应条件

温度: 50 °C

PROCEDURE

实验过程

A mixture of 3-(2,4-dimethoxybenzyl)-6-ethylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione (3.4 g), 3′-bromo-4′-(bromomethyl)biphenyl-2-carbonitrile (3.8 g), potassium carbonate (2.7 g) and acetonitrile (200 mL) was stirred at 50° C. for 2 hr. Insoluble material was filtered off, and the solvent was evaporated under reduced pressure. The precipitated solid was collected by filtration to give the title compound as a colorless solid (4.92 g, 81%).

WORKUP

后处理

filtrationInsoluble material was filtered off
customthe solvent was evaporated under reduced pressure
filtrationThe precipitated solid was collected by filtration

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d95b627820364b0b8346a01502883fda
来源数据集: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08501750B2
来源说明: uspto-grants-2013_08

反应 SMILES

[CH3:1][O:2][C:3]1[CH:22]=[C:21]([O:23][CH3:24])[CH:20]=[CH:19][C:4]=1[CH2:5][N:6]1[C:11](=[O:12])[C:10]2[CH:13]=[C:14]([CH2:16][CH3:17])[S:15][C:9]=2[NH:8][C:7]1=[O:18].[Br:25][C:26]1[CH:27]=[C:28]([C:34]2[C:35]([C:40]#[N:41])=[CH:36][CH:37]=[CH:38][CH:39]=2)[CH:29]=[CH:30][C:31]=1[CH2:32]Br.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[Br:25][C:26]1[CH:27]=[C:28]([C:34]2[C:35]([C:40]#[N:41])=[CH:36][CH:37]=[CH:38][CH:39]=2)[CH:29]=[CH:30][C:31]=1[CH2:32][N:8]1[C:9]2[S:15][C:14]([CH2:16][CH3:17])=[CH:13][C:10]=2[C:11](=[O:12])[N:6]([CH2:5][C:4]2[CH:19]=[CH:20][C:21]([O:23][CH3:24])=[CH:22][C:3]=2[O:2][CH3:1])[C:7]1=[O:18]